GrippeBelgiqueV4, Main, Exploration, bibRecord, 000057

Pandemic A/H1N1v influenza 2009 in hospitalized children: a multicenter Belgian survey.

Identifieur interne : 000057 ( Main/Exploration ); précédent : 000056; suivant : 000058

Pandemic A/H1N1v influenza 2009 in hospitalized children: a multicenter Belgian survey.

Auteurs : Sophie Blumental [Belgique] ; Elisabeth Huisman ; Marie-Coralie Cornet ; Christine Ferreiro ; Iris De Schutter ; Marijke Reynders ; Ingrid Wybo ; Benoît Kabamba-Mukadi ; Ruth Armano ; Dominique Hermans ; Marie-Cécile Nassogne ; Bhavna Mahadeb ; Christine Fonteyne ; Gerlant Van Berlaer ; Jack Levy ; Didier Moulin ; Anne Vergison ; Anne Malfroot ; Philippe Lepage

Source :

BMC infectious diseases [ 1471-2334 ] ; 2011.

RBID : pubmed:22060843

Descripteurs français

KwdFr :
- Adolescent, Analyse de survie, Antibactériens (usage thérapeutique), Antiviraux (usage thérapeutique), Belgique (épidémiologie), Enfant, Enfant d'âge préscolaire, Enfant hospitalisé, Femelle, Grippe humaine (), Grippe humaine (anatomopathologie), Grippe humaine (traitement médicamenteux), Grippe humaine (épidémiologie), Humains, Maladies de l'appareil respiratoire (anatomopathologie), Maladies de l'appareil respiratoire (diagnostic), Maladies de l'appareil respiratoire (traitement médicamenteux), Maladies de l'appareil respiratoire (épidémiologie), Maladies du système nerveux (anatomopathologie), Maladies du système nerveux (diagnostic), Maladies du système nerveux (traitement médicamenteux), Maladies du système nerveux (épidémiologie), Maladies gastro-intestinales (anatomopathologie), Maladies gastro-intestinales (diagnostic), Maladies gastro-intestinales (traitement médicamenteux), Maladies gastro-intestinales (épidémiologie), Mâle, Nourrisson, Nouveau-né, Oséltamivir (usage thérapeutique), Pandémies, Répartition par âge, Soins de réanimation ().
MESH :
- anatomopathologie : Grippe humaine, Maladies de l'appareil respiratoire, Maladies du système nerveux, Maladies gastro-intestinales.
- diagnostic : Maladies de l'appareil respiratoire, Maladies du système nerveux, Maladies gastro-intestinales.
- traitement médicamenteux : Grippe humaine, Maladies de l'appareil respiratoire, Maladies du système nerveux, Maladies gastro-intestinales.
- usage thérapeutique : Antibactériens, Antiviraux, Oséltamivir.
- épidémiologie : Belgique, Grippe humaine, Maladies de l'appareil respiratoire, Maladies du système nerveux, Maladies gastro-intestinales.
- Adolescent, Analyse de survie, Enfant, Enfant d'âge préscolaire, Enfant hospitalisé, Femelle, Grippe humaine, Humains, Mâle, Nourrisson, Nouveau-né, Pandémies, Répartition par âge, Soins de réanimation.
Wicri :
- geographic : Belgique.

English descriptors

KwdEn :
- Adolescent, Age Distribution, Anti-Bacterial Agents (therapeutic use), Antiviral Agents (therapeutic use), Belgium (epidemiology), Child, Child, Hospitalized, Child, Preschool, Critical Care (statistics & numerical data), Female, Gastrointestinal Diseases (diagnosis), Gastrointestinal Diseases (drug therapy), Gastrointestinal Diseases (epidemiology), Gastrointestinal Diseases (pathology), Humans, Infant, Infant, Newborn, Influenza, Human (complications), Influenza, Human (drug therapy), Influenza, Human (epidemiology), Influenza, Human (pathology), Male, Nervous System Diseases (diagnosis), Nervous System Diseases (drug therapy), Nervous System Diseases (epidemiology), Nervous System Diseases (pathology), Oseltamivir (therapeutic use), Pandemics, Respiratory Tract Diseases (diagnosis), Respiratory Tract Diseases (drug therapy), Respiratory Tract Diseases (epidemiology), Respiratory Tract Diseases (pathology), Survival Analysis.
MESH :
- chemical , therapeutic use : Anti-Bacterial Agents, Antiviral Agents, Oseltamivir.
- geographic , epidemiology : Belgium.
- complications : Influenza, Human.
- diagnosis : Gastrointestinal Diseases, Nervous System Diseases, Respiratory Tract Diseases.
- drug therapy : Gastrointestinal Diseases, Influenza, Human, Nervous System Diseases, Respiratory Tract Diseases.
- epidemiology : Gastrointestinal Diseases, Influenza, Human, Nervous System Diseases, Respiratory Tract Diseases.
- pathology : Gastrointestinal Diseases, Influenza, Human, Nervous System Diseases, Respiratory Tract Diseases.
- statistics & numerical data : Critical Care.
- Adolescent, Age Distribution, Child, Child, Hospitalized, Child, Preschool, Female, Humans, Infant, Infant, Newborn, Male, Pandemics, Survival Analysis.

Abstract

BACKGROUND

During the 2009 influenza A/H1N1v pandemic, children were identified as a specific "at risk" group. We conducted a multicentric study to describe pattern of influenza A/H1N1v infection among hospitalized children in Brussels, Belgium.

METHODS

From July 1, 2009, to January 31, 2010, we collected epidemiological and clinical data of all proven (positive H1N1v PCR) and probable (positive influenza A antigen or culture) pediatric cases of influenza A/H1N1v infections, hospitalized in four tertiary centers.

RESULTS

During the epidemic period, an excess of 18% of pediatric outpatients and emergency department visits was registered. 215 children were hospitalized with proven/probable influenza A/H1N1v infection. Median age was 31 months. 47% had ≥ 1 comorbid conditions. Febrile respiratory illness was the most common presentation. 36% presented with initial gastrointestinal symptoms and 10% with neurological manifestations. 34% had pneumonia. Only 24% of the patients received oseltamivir but 57% received antibiotics. 10% of children were admitted to PICU, seven of whom with ARDS. Case fatality-rate was 5/215 (2%), concerning only children suffering from chronic neurological disorders. Children over 2 years of age showed a higher propensity to be admitted to PICU (16% vs 1%, p = 0.002) and a higher mortality rate (4% vs 0%, p = 0.06). Infants less than 3 months old showed a milder course of infection, with few respiratory and neurological complications.

CONCLUSION

Although influenza A/H1N1v infections were generally self-limited, pediatric burden of disease was significant. Compared to other countries experiencing different health care systems, our Belgian cohort was younger and received less frequently antiviral therapy; disease course and mortality were however similar.

DOI: 10.1186/1471-2334-11-313
PubMed: 22060843

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 000061
to stream Main, to step Curation: 000061

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Pandemic A/H1N1v influenza 2009 in hospitalized children: a multicenter Belgian survey.</title>
<author><name sortKey="Blumental, Sophie" sort="Blumental, Sophie" uniqKey="Blumental S" first="Sophie" last="Blumental">Sophie Blumental</name>
<affiliation wicri:level="3"><nlm:affiliation>Pediatric Infectious Diseases Unit, Hôpital Universitaire des Enfants Reine Fabiola (HUDERF), Brussels, Belgium. sophie.blumental@ulb.ac.be</nlm:affiliation>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Pediatric Infectious Diseases Unit, Hôpital Universitaire des Enfants Reine Fabiola (HUDERF), Brussels</wicri:regionArea>
<placeName><settlement type="city">Bruxelles</settlement>
<region nuts="2">Région de Bruxelles-Capitale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Huisman, Elisabeth" sort="Huisman, Elisabeth" uniqKey="Huisman E" first="Elisabeth" last="Huisman">Elisabeth Huisman</name>
</author>
<author><name sortKey="Cornet, Marie Coralie" sort="Cornet, Marie Coralie" uniqKey="Cornet M" first="Marie-Coralie" last="Cornet">Marie-Coralie Cornet</name>
</author>
<author><name sortKey="Ferreiro, Christine" sort="Ferreiro, Christine" uniqKey="Ferreiro C" first="Christine" last="Ferreiro">Christine Ferreiro</name>
</author>
<author><name sortKey="De Schutter, Iris" sort="De Schutter, Iris" uniqKey="De Schutter I" first="Iris" last="De Schutter">Iris De Schutter</name>
</author>
<author><name sortKey="Reynders, Marijke" sort="Reynders, Marijke" uniqKey="Reynders M" first="Marijke" last="Reynders">Marijke Reynders</name>
</author>
<author><name sortKey="Wybo, Ingrid" sort="Wybo, Ingrid" uniqKey="Wybo I" first="Ingrid" last="Wybo">Ingrid Wybo</name>
</author>
<author><name sortKey="Kabamba Mukadi, Benoit" sort="Kabamba Mukadi, Benoit" uniqKey="Kabamba Mukadi B" first="Benoît" last="Kabamba-Mukadi">Benoît Kabamba-Mukadi</name>
</author>
<author><name sortKey="Armano, Ruth" sort="Armano, Ruth" uniqKey="Armano R" first="Ruth" last="Armano">Ruth Armano</name>
</author>
<author><name sortKey="Hermans, Dominique" sort="Hermans, Dominique" uniqKey="Hermans D" first="Dominique" last="Hermans">Dominique Hermans</name>
</author>
<author><name sortKey="Nassogne, Marie Cecile" sort="Nassogne, Marie Cecile" uniqKey="Nassogne M" first="Marie-Cécile" last="Nassogne">Marie-Cécile Nassogne</name>
</author>
<author><name sortKey="Mahadeb, Bhavna" sort="Mahadeb, Bhavna" uniqKey="Mahadeb B" first="Bhavna" last="Mahadeb">Bhavna Mahadeb</name>
</author>
<author><name sortKey="Fonteyne, Christine" sort="Fonteyne, Christine" uniqKey="Fonteyne C" first="Christine" last="Fonteyne">Christine Fonteyne</name>
</author>
<author><name sortKey="Van Berlaer, Gerlant" sort="Van Berlaer, Gerlant" uniqKey="Van Berlaer G" first="Gerlant" last="Van Berlaer">Gerlant Van Berlaer</name>
</author>
<author><name sortKey="Levy, Jack" sort="Levy, Jack" uniqKey="Levy J" first="Jack" last="Levy">Jack Levy</name>
</author>
<author><name sortKey="Moulin, Didier" sort="Moulin, Didier" uniqKey="Moulin D" first="Didier" last="Moulin">Didier Moulin</name>
</author>
<author><name sortKey="Vergison, Anne" sort="Vergison, Anne" uniqKey="Vergison A" first="Anne" last="Vergison">Anne Vergison</name>
</author>
<author><name sortKey="Malfroot, Anne" sort="Malfroot, Anne" uniqKey="Malfroot A" first="Anne" last="Malfroot">Anne Malfroot</name>
</author>
<author><name sortKey="Lepage, Philippe" sort="Lepage, Philippe" uniqKey="Lepage P" first="Philippe" last="Lepage">Philippe Lepage</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2011">2011</date>
<idno type="RBID">pubmed:22060843</idno>
<idno type="pmid">22060843</idno>
<idno type="doi">10.1186/1471-2334-11-313</idno>
<idno type="wicri:Area/Main/Corpus">000061</idno>
<idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000061</idno>
<idno type="wicri:Area/Main/Curation">000061</idno>
<idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000061</idno>
<idno type="wicri:Area/Main/Exploration">000061</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Pandemic A/H1N1v influenza 2009 in hospitalized children: a multicenter Belgian survey.</title>
<author><name sortKey="Blumental, Sophie" sort="Blumental, Sophie" uniqKey="Blumental S" first="Sophie" last="Blumental">Sophie Blumental</name>
<affiliation wicri:level="3"><nlm:affiliation>Pediatric Infectious Diseases Unit, Hôpital Universitaire des Enfants Reine Fabiola (HUDERF), Brussels, Belgium. sophie.blumental@ulb.ac.be</nlm:affiliation>
<country xml:lang="fr">Belgique</country>
<wicri:regionArea>Pediatric Infectious Diseases Unit, Hôpital Universitaire des Enfants Reine Fabiola (HUDERF), Brussels</wicri:regionArea>
<placeName><settlement type="city">Bruxelles</settlement>
<region nuts="2">Région de Bruxelles-Capitale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Huisman, Elisabeth" sort="Huisman, Elisabeth" uniqKey="Huisman E" first="Elisabeth" last="Huisman">Elisabeth Huisman</name>
</author>
<author><name sortKey="Cornet, Marie Coralie" sort="Cornet, Marie Coralie" uniqKey="Cornet M" first="Marie-Coralie" last="Cornet">Marie-Coralie Cornet</name>
</author>
<author><name sortKey="Ferreiro, Christine" sort="Ferreiro, Christine" uniqKey="Ferreiro C" first="Christine" last="Ferreiro">Christine Ferreiro</name>
</author>
<author><name sortKey="De Schutter, Iris" sort="De Schutter, Iris" uniqKey="De Schutter I" first="Iris" last="De Schutter">Iris De Schutter</name>
</author>
<author><name sortKey="Reynders, Marijke" sort="Reynders, Marijke" uniqKey="Reynders M" first="Marijke" last="Reynders">Marijke Reynders</name>
</author>
<author><name sortKey="Wybo, Ingrid" sort="Wybo, Ingrid" uniqKey="Wybo I" first="Ingrid" last="Wybo">Ingrid Wybo</name>
</author>
<author><name sortKey="Kabamba Mukadi, Benoit" sort="Kabamba Mukadi, Benoit" uniqKey="Kabamba Mukadi B" first="Benoît" last="Kabamba-Mukadi">Benoît Kabamba-Mukadi</name>
</author>
<author><name sortKey="Armano, Ruth" sort="Armano, Ruth" uniqKey="Armano R" first="Ruth" last="Armano">Ruth Armano</name>
</author>
<author><name sortKey="Hermans, Dominique" sort="Hermans, Dominique" uniqKey="Hermans D" first="Dominique" last="Hermans">Dominique Hermans</name>
</author>
<author><name sortKey="Nassogne, Marie Cecile" sort="Nassogne, Marie Cecile" uniqKey="Nassogne M" first="Marie-Cécile" last="Nassogne">Marie-Cécile Nassogne</name>
</author>
<author><name sortKey="Mahadeb, Bhavna" sort="Mahadeb, Bhavna" uniqKey="Mahadeb B" first="Bhavna" last="Mahadeb">Bhavna Mahadeb</name>
</author>
<author><name sortKey="Fonteyne, Christine" sort="Fonteyne, Christine" uniqKey="Fonteyne C" first="Christine" last="Fonteyne">Christine Fonteyne</name>
</author>
<author><name sortKey="Van Berlaer, Gerlant" sort="Van Berlaer, Gerlant" uniqKey="Van Berlaer G" first="Gerlant" last="Van Berlaer">Gerlant Van Berlaer</name>
</author>
<author><name sortKey="Levy, Jack" sort="Levy, Jack" uniqKey="Levy J" first="Jack" last="Levy">Jack Levy</name>
</author>
<author><name sortKey="Moulin, Didier" sort="Moulin, Didier" uniqKey="Moulin D" first="Didier" last="Moulin">Didier Moulin</name>
</author>
<author><name sortKey="Vergison, Anne" sort="Vergison, Anne" uniqKey="Vergison A" first="Anne" last="Vergison">Anne Vergison</name>
</author>
<author><name sortKey="Malfroot, Anne" sort="Malfroot, Anne" uniqKey="Malfroot A" first="Anne" last="Malfroot">Anne Malfroot</name>
</author>
<author><name sortKey="Lepage, Philippe" sort="Lepage, Philippe" uniqKey="Lepage P" first="Philippe" last="Lepage">Philippe Lepage</name>
</author>
</analytic>
<series><title level="j">BMC infectious diseases</title>
<idno type="eISSN">1471-2334</idno>
<imprint><date when="2011" type="published">2011</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term>
<term>Age Distribution</term>
<term>Anti-Bacterial Agents (therapeutic use)</term>
<term>Antiviral Agents (therapeutic use)</term>
<term>Belgium (epidemiology)</term>
<term>Child</term>
<term>Child, Hospitalized</term>
<term>Child, Preschool</term>
<term>Critical Care (statistics & numerical data)</term>
<term>Female</term>
<term>Gastrointestinal Diseases (diagnosis)</term>
<term>Gastrointestinal Diseases (drug therapy)</term>
<term>Gastrointestinal Diseases (epidemiology)</term>
<term>Gastrointestinal Diseases (pathology)</term>
<term>Humans</term>
<term>Infant</term>
<term>Infant, Newborn</term>
<term>Influenza, Human (complications)</term>
<term>Influenza, Human (drug therapy)</term>
<term>Influenza, Human (epidemiology)</term>
<term>Influenza, Human (pathology)</term>
<term>Male</term>
<term>Nervous System Diseases (diagnosis)</term>
<term>Nervous System Diseases (drug therapy)</term>
<term>Nervous System Diseases (epidemiology)</term>
<term>Nervous System Diseases (pathology)</term>
<term>Oseltamivir (therapeutic use)</term>
<term>Pandemics</term>
<term>Respiratory Tract Diseases (diagnosis)</term>
<term>Respiratory Tract Diseases (drug therapy)</term>
<term>Respiratory Tract Diseases (epidemiology)</term>
<term>Respiratory Tract Diseases (pathology)</term>
<term>Survival Analysis</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term>
<term>Analyse de survie</term>
<term>Antibactériens (usage thérapeutique)</term>
<term>Antiviraux (usage thérapeutique)</term>
<term>Belgique (épidémiologie)</term>
<term>Enfant</term>
<term>Enfant d'âge préscolaire</term>
<term>Enfant hospitalisé</term>
<term>Femelle</term>
<term>Grippe humaine ()</term>
<term>Grippe humaine (anatomopathologie)</term>
<term>Grippe humaine (traitement médicamenteux)</term>
<term>Grippe humaine (épidémiologie)</term>
<term>Humains</term>
<term>Maladies de l'appareil respiratoire (anatomopathologie)</term>
<term>Maladies de l'appareil respiratoire (diagnostic)</term>
<term>Maladies de l'appareil respiratoire (traitement médicamenteux)</term>
<term>Maladies de l'appareil respiratoire (épidémiologie)</term>
<term>Maladies du système nerveux (anatomopathologie)</term>
<term>Maladies du système nerveux (diagnostic)</term>
<term>Maladies du système nerveux (traitement médicamenteux)</term>
<term>Maladies du système nerveux (épidémiologie)</term>
<term>Maladies gastro-intestinales (anatomopathologie)</term>
<term>Maladies gastro-intestinales (diagnostic)</term>
<term>Maladies gastro-intestinales (traitement médicamenteux)</term>
<term>Maladies gastro-intestinales (épidémiologie)</term>
<term>Mâle</term>
<term>Nourrisson</term>
<term>Nouveau-né</term>
<term>Oséltamivir (usage thérapeutique)</term>
<term>Pandémies</term>
<term>Répartition par âge</term>
<term>Soins de réanimation ()</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Anti-Bacterial Agents</term>
<term>Antiviral Agents</term>
<term>Oseltamivir</term>
</keywords>
<keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Belgium</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Grippe humaine</term>
<term>Maladies de l'appareil respiratoire</term>
<term>Maladies du système nerveux</term>
<term>Maladies gastro-intestinales</term>
</keywords>
<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Influenza, Human</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Gastrointestinal Diseases</term>
<term>Nervous System Diseases</term>
<term>Respiratory Tract Diseases</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Maladies de l'appareil respiratoire</term>
<term>Maladies du système nerveux</term>
<term>Maladies gastro-intestinales</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Gastrointestinal Diseases</term>
<term>Influenza, Human</term>
<term>Nervous System Diseases</term>
<term>Respiratory Tract Diseases</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Gastrointestinal Diseases</term>
<term>Influenza, Human</term>
<term>Nervous System Diseases</term>
<term>Respiratory Tract Diseases</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Gastrointestinal Diseases</term>
<term>Influenza, Human</term>
<term>Nervous System Diseases</term>
<term>Respiratory Tract Diseases</term>
</keywords>
<keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en"><term>Critical Care</term>
</keywords>
<keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Grippe humaine</term>
<term>Maladies de l'appareil respiratoire</term>
<term>Maladies du système nerveux</term>
<term>Maladies gastro-intestinales</term>
</keywords>
<keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Antibactériens</term>
<term>Antiviraux</term>
<term>Oséltamivir</term>
</keywords>
<keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Belgique</term>
<term>Grippe humaine</term>
<term>Maladies de l'appareil respiratoire</term>
<term>Maladies du système nerveux</term>
<term>Maladies gastro-intestinales</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adolescent</term>
<term>Age Distribution</term>
<term>Child</term>
<term>Child, Hospitalized</term>
<term>Child, Preschool</term>
<term>Female</term>
<term>Humans</term>
<term>Infant</term>
<term>Infant, Newborn</term>
<term>Male</term>
<term>Pandemics</term>
<term>Survival Analysis</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term>
<term>Analyse de survie</term>
<term>Enfant</term>
<term>Enfant d'âge préscolaire</term>
<term>Enfant hospitalisé</term>
<term>Femelle</term>
<term>Grippe humaine</term>
<term>Humains</term>
<term>Mâle</term>
<term>Nourrisson</term>
<term>Nouveau-né</term>
<term>Pandémies</term>
<term>Répartition par âge</term>
<term>Soins de réanimation</term>
</keywords>
<keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Belgique</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b>
</p>
<p>During the 2009 influenza A/H1N1v pandemic, children were identified as a specific "at risk" group. We conducted a multicentric study to describe pattern of influenza A/H1N1v infection among hospitalized children in Brussels, Belgium.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>METHODS</b>
</p>
<p>From July 1, 2009, to January 31, 2010, we collected epidemiological and clinical data of all proven (positive H1N1v PCR) and probable (positive influenza A antigen or culture) pediatric cases of influenza A/H1N1v infections, hospitalized in four tertiary centers.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>RESULTS</b>
</p>
<p>During the epidemic period, an excess of 18% of pediatric outpatients and emergency department visits was registered. 215 children were hospitalized with proven/probable influenza A/H1N1v infection. Median age was 31 months. 47% had ≥ 1 comorbid conditions. Febrile respiratory illness was the most common presentation. 36% presented with initial gastrointestinal symptoms and 10% with neurological manifestations. 34% had pneumonia. Only 24% of the patients received oseltamivir but 57% received antibiotics. 10% of children were admitted to PICU, seven of whom with ARDS. Case fatality-rate was 5/215 (2%), concerning only children suffering from chronic neurological disorders. Children over 2 years of age showed a higher propensity to be admitted to PICU (16% vs 1%, p = 0.002) and a higher mortality rate (4% vs 0%, p = 0.06). Infants less than 3 months old showed a milder course of infection, with few respiratory and neurological complications.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>CONCLUSION</b>
</p>
<p>Although influenza A/H1N1v infections were generally self-limited, pediatric burden of disease was significant. Compared to other countries experiencing different health care systems, our Belgian cohort was younger and received less frequently antiviral therapy; disease course and mortality were however similar.</p>
</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">22060843</PMID>
<DateCompleted><Year>2012</Year>
<Month>02</Month>
<Day>07</Day>
</DateCompleted>
<DateRevised><Year>2018</Year>
<Month>11</Month>
<Day>13</Day>
</DateRevised>
<Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">1471-2334</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>11</Volume>
<PubDate><Year>2011</Year>
<Month>Nov</Month>
<Day>07</Day>
</PubDate>
</JournalIssue>
<Title>BMC infectious diseases</Title>
<ISOAbbreviation>BMC Infect. Dis.</ISOAbbreviation>
</Journal>
<ArticleTitle>Pandemic A/H1N1v influenza 2009 in hospitalized children: a multicenter Belgian survey.</ArticleTitle>
<Pagination><MedlinePgn>313</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1186/1471-2334-11-313</ELocationID>
<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">During the 2009 influenza A/H1N1v pandemic, children were identified as a specific "at risk" group. We conducted a multicentric study to describe pattern of influenza A/H1N1v infection among hospitalized children in Brussels, Belgium.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">From July 1, 2009, to January 31, 2010, we collected epidemiological and clinical data of all proven (positive H1N1v PCR) and probable (positive influenza A antigen or culture) pediatric cases of influenza A/H1N1v infections, hospitalized in four tertiary centers.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">During the epidemic period, an excess of 18% of pediatric outpatients and emergency department visits was registered. 215 children were hospitalized with proven/probable influenza A/H1N1v infection. Median age was 31 months. 47% had ≥ 1 comorbid conditions. Febrile respiratory illness was the most common presentation. 36% presented with initial gastrointestinal symptoms and 10% with neurological manifestations. 34% had pneumonia. Only 24% of the patients received oseltamivir but 57% received antibiotics. 10% of children were admitted to PICU, seven of whom with ARDS. Case fatality-rate was 5/215 (2%), concerning only children suffering from chronic neurological disorders. Children over 2 years of age showed a higher propensity to be admitted to PICU (16% vs 1%, p = 0.002) and a higher mortality rate (4% vs 0%, p = 0.06). Infants less than 3 months old showed a milder course of infection, with few respiratory and neurological complications.</AbstractText>
<AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">Although influenza A/H1N1v infections were generally self-limited, pediatric burden of disease was significant. Compared to other countries experiencing different health care systems, our Belgian cohort was younger and received less frequently antiviral therapy; disease course and mortality were however similar.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Blumental</LastName>
<ForeName>Sophie</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Pediatric Infectious Diseases Unit, Hôpital Universitaire des Enfants Reine Fabiola (HUDERF), Brussels, Belgium. sophie.blumental@ulb.ac.be</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Huisman</LastName>
<ForeName>Elisabeth</ForeName>
<Initials>E</Initials>
</Author>
<Author ValidYN="Y"><LastName>Cornet</LastName>
<ForeName>Marie-Coralie</ForeName>
<Initials>MC</Initials>
</Author>
<Author ValidYN="Y"><LastName>Ferreiro</LastName>
<ForeName>Christine</ForeName>
<Initials>C</Initials>
</Author>
<Author ValidYN="Y"><LastName>De Schutter</LastName>
<ForeName>Iris</ForeName>
<Initials>I</Initials>
</Author>
<Author ValidYN="Y"><LastName>Reynders</LastName>
<ForeName>Marijke</ForeName>
<Initials>M</Initials>
</Author>
<Author ValidYN="Y"><LastName>Wybo</LastName>
<ForeName>Ingrid</ForeName>
<Initials>I</Initials>
</Author>
<Author ValidYN="Y"><LastName>Kabamba-Mukadi</LastName>
<ForeName>Benoît</ForeName>
<Initials>B</Initials>
</Author>
<Author ValidYN="Y"><LastName>Armano</LastName>
<ForeName>Ruth</ForeName>
<Initials>R</Initials>
</Author>
<Author ValidYN="Y"><LastName>Hermans</LastName>
<ForeName>Dominique</ForeName>
<Initials>D</Initials>
</Author>
<Author ValidYN="Y"><LastName>Nassogne</LastName>
<ForeName>Marie-Cécile</ForeName>
<Initials>MC</Initials>
</Author>
<Author ValidYN="Y"><LastName>Mahadeb</LastName>
<ForeName>Bhavna</ForeName>
<Initials>B</Initials>
</Author>
<Author ValidYN="Y"><LastName>Fonteyne</LastName>
<ForeName>Christine</ForeName>
<Initials>C</Initials>
</Author>
<Author ValidYN="Y"><LastName>Van Berlaer</LastName>
<ForeName>Gerlant</ForeName>
<Initials>G</Initials>
</Author>
<Author ValidYN="Y"><LastName>Levy</LastName>
<ForeName>Jack</ForeName>
<Initials>J</Initials>
</Author>
<Author ValidYN="Y"><LastName>Moulin</LastName>
<ForeName>Didier</ForeName>
<Initials>D</Initials>
</Author>
<Author ValidYN="Y"><LastName>Vergison</LastName>
<ForeName>Anne</ForeName>
<Initials>A</Initials>
</Author>
<Author ValidYN="Y"><LastName>Malfroot</LastName>
<ForeName>Anne</ForeName>
<Initials>A</Initials>
</Author>
<Author ValidYN="Y"><LastName>Lepage</LastName>
<ForeName>Philippe</ForeName>
<Initials>P</Initials>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D016448">Multicenter Study</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2011</Year>
<Month>11</Month>
<Day>07</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>England</Country>
<MedlineTA>BMC Infect Dis</MedlineTA>
<NlmUniqueID>100968551</NlmUniqueID>
<ISSNLinking>1471-2334</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D000900">Anti-Bacterial Agents</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D000998">Antiviral Agents</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>20O93L6F9H</RegistryNumber>
<NameOfSubstance UI="D053139">Oseltamivir</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D017677" MajorTopicYN="N">Age Distribution</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000900" MajorTopicYN="N">Anti-Bacterial Agents</DescriptorName>
<QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000998" MajorTopicYN="N">Antiviral Agents</DescriptorName>
<QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D001530" MajorTopicYN="N" Type="Geographic">Belgium</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002648" MajorTopicYN="N">Child</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002673" MajorTopicYN="N">Child, Hospitalized</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002675" MajorTopicYN="N">Child, Preschool</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D003422" MajorTopicYN="N">Critical Care</DescriptorName>
<QualifierName UI="Q000706" MajorTopicYN="N">statistics & numerical data</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005767" MajorTopicYN="N">Gastrointestinal Diseases</DescriptorName>
<QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName>
<QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName>
<QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
<QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007223" MajorTopicYN="N">Infant</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007231" MajorTopicYN="N">Infant, Newborn</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007251" MajorTopicYN="N">Influenza, Human</DescriptorName>
<QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName>
<QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName>
<QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName>
<QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D009422" MajorTopicYN="N">Nervous System Diseases</DescriptorName>
<QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName>
<QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName>
<QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
<QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D053139" MajorTopicYN="N">Oseltamivir</DescriptorName>
<QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D058873" MajorTopicYN="Y">Pandemics</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012140" MajorTopicYN="N">Respiratory Tract Diseases</DescriptorName>
<QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName>
<QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName>
<QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
<QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016019" MajorTopicYN="N">Survival Analysis</DescriptorName>
</MeshHeading>
</MeshHeadingList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2011</Year>
<Month>07</Month>
<Day>29</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2011</Year>
<Month>11</Month>
<Day>07</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2011</Year>
<Month>11</Month>
<Day>9</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2011</Year>
<Month>11</Month>
<Day>9</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2012</Year>
<Month>2</Month>
<Day>9</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>epublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">22060843</ArticleId>
<ArticleId IdType="pii">1471-2334-11-313</ArticleId>
<ArticleId IdType="doi">10.1186/1471-2334-11-313</ArticleId>
<ArticleId IdType="pmc">PMC3224785</ArticleId>
</ArticleIdList>
<ReferenceList><Reference><Citation>Pediatrics. 2008 Oct;122(4):805-11</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18829805</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Clin Microbiol Rev. 2007 Jan;20(1):49-78</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17223623</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Science. 2009 Jul 24;325(5939):481-3</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19574348</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Lancet. 2009 Aug 22;374(9690):605</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19700001</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>MMWR Morb Mortal Wkly Rep. 2009 Sep 4;58(34):941-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19730406</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Am J Respir Crit Care Med. 2010 Jan 1;181(1):72-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19875682</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Arch Pediatr Adolesc Med. 2010 Jan;164(1):24-30</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20048238</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>N Engl J Med. 2010 Jan 7;362(1):45-55</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20032320</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Lancet. 2009 Dec 19;374(9707):2072-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19913290</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Lancet. 2010 Mar 27;375(9720):1100-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20096450</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Vaccine. 2010 Apr 19;28(18):3180-4</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20189488</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>N Engl J Med. 2010 May 6;362(18):1708-19</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20445182</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Arch Pediatr Adolesc Med. 2010 Nov;164(11):1015-22</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21041594</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Arch Pediatr Adolesc Med. 2010 Nov;164(11):1023-31</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21041595</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Lancet. 2010 Nov 27;376(9755):1846-52</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21030071</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Pediatrics. 2011 Jan;127(1):e156-63</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21172991</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>MMWR Recomm Rep. 2011 Jan 21;60(1):1-24</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21248682</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Clin Infect Dis. 2011 Jan 1;52 Suppl 1:S50-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21342900</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Clin Infect Dis. 2011 Jan 1;52 Suppl 1:S69-74</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21342902</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Eur J Pediatr. 2011 Mar;170(3):371-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21274563</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Pediatr Infect Dis J. 2011 Jun;30(6):475-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21206393</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Acta Paediatr. 2012 Jan;101(1):67-72</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21767303</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Acta Clin Belg. 2012 Mar-Apr;67(2):94-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22712164</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>N Engl J Med. 2002 Feb 7;346(6):429-37</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11832532</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Arch Pediatr Adolesc Med. 2003 Apr;157(4):389-92</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12695236</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>N Engl J Med. 2005 Dec 15;353(24):2559-67</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16354892</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Pediatr Clin North Am. 2006 Apr;53(2):167-94</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16574521</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Pediatr Ann. 2008 Oct;37(10):673-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18972849</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>Belgique</li>
</country>
<region><li>Région de Bruxelles-Capitale</li>
</region>
<settlement><li>Bruxelles</li>
</settlement>
</list>
<tree><noCountry><name sortKey="Armano, Ruth" sort="Armano, Ruth" uniqKey="Armano R" first="Ruth" last="Armano">Ruth Armano</name>
<name sortKey="Cornet, Marie Coralie" sort="Cornet, Marie Coralie" uniqKey="Cornet M" first="Marie-Coralie" last="Cornet">Marie-Coralie Cornet</name>
<name sortKey="De Schutter, Iris" sort="De Schutter, Iris" uniqKey="De Schutter I" first="Iris" last="De Schutter">Iris De Schutter</name>
<name sortKey="Ferreiro, Christine" sort="Ferreiro, Christine" uniqKey="Ferreiro C" first="Christine" last="Ferreiro">Christine Ferreiro</name>
<name sortKey="Fonteyne, Christine" sort="Fonteyne, Christine" uniqKey="Fonteyne C" first="Christine" last="Fonteyne">Christine Fonteyne</name>
<name sortKey="Hermans, Dominique" sort="Hermans, Dominique" uniqKey="Hermans D" first="Dominique" last="Hermans">Dominique Hermans</name>
<name sortKey="Huisman, Elisabeth" sort="Huisman, Elisabeth" uniqKey="Huisman E" first="Elisabeth" last="Huisman">Elisabeth Huisman</name>
<name sortKey="Kabamba Mukadi, Benoit" sort="Kabamba Mukadi, Benoit" uniqKey="Kabamba Mukadi B" first="Benoît" last="Kabamba-Mukadi">Benoît Kabamba-Mukadi</name>
<name sortKey="Lepage, Philippe" sort="Lepage, Philippe" uniqKey="Lepage P" first="Philippe" last="Lepage">Philippe Lepage</name>
<name sortKey="Levy, Jack" sort="Levy, Jack" uniqKey="Levy J" first="Jack" last="Levy">Jack Levy</name>
<name sortKey="Mahadeb, Bhavna" sort="Mahadeb, Bhavna" uniqKey="Mahadeb B" first="Bhavna" last="Mahadeb">Bhavna Mahadeb</name>
<name sortKey="Malfroot, Anne" sort="Malfroot, Anne" uniqKey="Malfroot A" first="Anne" last="Malfroot">Anne Malfroot</name>
<name sortKey="Moulin, Didier" sort="Moulin, Didier" uniqKey="Moulin D" first="Didier" last="Moulin">Didier Moulin</name>
<name sortKey="Nassogne, Marie Cecile" sort="Nassogne, Marie Cecile" uniqKey="Nassogne M" first="Marie-Cécile" last="Nassogne">Marie-Cécile Nassogne</name>
<name sortKey="Reynders, Marijke" sort="Reynders, Marijke" uniqKey="Reynders M" first="Marijke" last="Reynders">Marijke Reynders</name>
<name sortKey="Van Berlaer, Gerlant" sort="Van Berlaer, Gerlant" uniqKey="Van Berlaer G" first="Gerlant" last="Van Berlaer">Gerlant Van Berlaer</name>
<name sortKey="Vergison, Anne" sort="Vergison, Anne" uniqKey="Vergison A" first="Anne" last="Vergison">Anne Vergison</name>
<name sortKey="Wybo, Ingrid" sort="Wybo, Ingrid" uniqKey="Wybo I" first="Ingrid" last="Wybo">Ingrid Wybo</name>
</noCountry>
<country name="Belgique"><region name="Région de Bruxelles-Capitale"><name sortKey="Blumental, Sophie" sort="Blumental, Sophie" uniqKey="Blumental S" first="Sophie" last="Blumental">Sophie Blumental</name>
</region>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/GrippeBelgiqueV4/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000057 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000057 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Sante
   |area=    GrippeBelgiqueV4
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     pubmed:22060843
   |texte=   Pandemic A/H1N1v influenza 2009 in hospitalized children: a multicenter Belgian survey.
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:22060843" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a GrippeBelgiqueV4

This area was generated with Dilib version V0.6.35.
Data generation: Mon Jul 6 21:52:38 2020. Site generation: Sat Sep 26 09:27:55 2020

	Corpus GrippeBelgiqueV4
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Corpus GrippeBelgiqueV4

Pandemic A/H1N1v influenza 2009 in hospitalized children: a multicenter Belgian survey.

Pandemic A/H1N1v influenza 2009 in hospitalized children: a multicenter Belgian survey.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki